Tuesday, September 20, 2022

Can Stress Cause Colon Cancer

For People At Increased Risk

Can stress or injuries cause Cancer Is it contagious? – Dr. Basawantrao Malipatil

Someone is at increased risk if they have a family history of colorectal cancer that includes 1 or more first-degree relatives with the disease.

If you are at increased risk of getting colorectal cancer, you should get screened with colonoscopy starting at age 50, or 10 years earlier than the age your relative was diagnosed, whichever comes first.

Avoid Common Cancer Triggers

Colorectal cancer is a last ditch response of the large intestine to the hostile environment created by the âend-user.â By âhostile environmentâ I mean the sum of all external and internal cancer triggers. When these triggers overpower your immune system, the malignancy takes over. Avoid these triggers, and you are less likely to ever experience colorectal cancer.

Just like with most other cancers, there are primary and secondary triggers of colorectal cancer. These triggers are represented by mechanical, chemical, and biological risk factors that may cause cell mutation , or the inflammation of the mucosal membrane that strips the colon and rectum from its innate protection against chemical, bacterial, and viral pathogens, or both.

The mechanical triggers include the already discussed large stools and straining. Technically, man-made x-ray and electromagnetic field radiation from power lines, cell phones, radars, and radio transmitters is also a mechanical trigger, although the radiation’s ultimate destructive action abnormal cellular mutation is biological.

The chemical triggers include medicines, alcohol, food additives, your own bile , and environmental hazards, such as herbicides, pesticides, heavy metals, dioxin, trans fats, and countless others.

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Sexuality And Bowel Cancer

Having bowel cancer and treatment can change the way you feel about yourself, other people, relationships and sex. These changes can be very upsetting and hard to talk about. Doctors and nurses are very understanding and can give you support. You can ask for a referral to a counsellor or therapist who specialises in body image, sex and relationships.

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Stress Inflammation And Cancer

Chronic stress has been demonstrated to account for a place in physiological and pathological disease outcomes, including several types of cancers . Chronic stress is thought to correlate with the etiology of tumor growth, progression and metastasis . In a clinical study of breast cancer patients 3 years post-treatment, elevated levels of stress-inducible acute phase proteins correlated with an increase in morbidity and mortality in the experimental cohort . Furthermore, animal experiment by using daily exposure to a novel environment to explore the effect of stress on the growth rate of SC115 carcinoma showed that social housing condition and novelty stress may lead to various impacts on the growth rate of tumor in mice . Metastasis is the main cause of death in cancer patients. Researchers demonstrated that chronic stress accelerates liver metastasis of colorectal cancer breast cancer and prostate cancer metastasis .

Coping With Physical Side Effects

Colon Cancer Causes And Risk Factors

Common physical side effects from each treatment option for colorectal cancer are listed in the Types of Treatment section. Learn more about side effects of cancer and its treatment, along with ways to prevent or control them. Changes to your physical health depend on several factors, including the cancers stage, the length and dose of treatment, and your general health. Many people who have been treated for colorectal cancer have difficulty eating at some point during treatment. Listen to a podcast about managing eating challenges after colorectal cancer treatment.

Talk with your health care team regularly about how you are feeling. It is important to let them know about any new side effects or changes in existing side effects. If they know how you are feeling, they can find ways to relieve or manage your side effects to help you feel more comfortable and potentially keep any side effects from worsening.

You may find it helpful to keep track of your side effects so it is easier to explain any changes with your health care team. Learn more about why tracking side effects is helpful.

Sometimes, side effects can last after treatment ends. Doctors call these long-term side effects. They call side effects that occur months or years after treatment late effects. Treating long-term side effects and late effects is an important part of survivorship care. Learn more by reading the Follow-up Care section of this guide or talking with your doctor.

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Opening The Floodgates For Research

Researchers have suspected that there might be a link between stress and cancer for some time. But the mechanism behind that link remains somewhat elusive, Dr. Hildesheim said. This study makes a significant contribution by identifying various components that might, in part, underlie that connection, he noted.

Whats more, this same mechanism could be contributing to cancer growth and treatment resistance in other ways, Dr. Hildesheim said. The nervous system could be impacting from multiple angles, he added.

A 2019 study, for example, showed that stress hormones can increase the number of pro-tumor immune cells in tumors. That could mean that stress not only wakes up dormant tumor cells but also provides the right environment for them to grow, Dr. Hildesheim explained.

Its the worst of both worlds, he said.

But, like Dr. Perego, he thinks its something that could be addressed by combining treatment approaches. Scientists are working to develop drugs that block the activity of or kill certain kinds of dormant cells called senescent cells. Finding ways to target senescent and dormant cells are two focuses of a recent partnership between NCI and Cancer Research UK.

Chemotherapy, radiation, and targeted therapy can all turn cancer cells into senescent cells. When combined with these traditional treatments, its possible that drugs that target senescent cells may prevent cancer from coming back, Dr. Hildesheim said.

When Cancer Cells Metastasize From Their Original Site They Become Dangerous They Invade Other Tissues Or Organs And Start The Process Of Developing More Tumors

Data published in Nature Reviews found that elevated cortisol suppresses the function of the NK cell, thus allowing viruses to take hold and cancer cells to survive in the body. Individuals under constant stress often have outbreaks of shingles and/or cold sores for some, stress causes the diagnosis or return of cancer. Additional research in The Lancet found that stress-induced suppression of NKcell activity caused tumor development.

Suppression of NK cells increases susceptibility to infectious agents influences the severity of infectious disease diminishes the strength of immune responses to vaccines reactivates latent herpes viruses and slows the healing of wounds.

In addition to NK cells, cytotoxic T cells, another group of cancer-killing white blood cells, recognize cancer by a certain ligand on the surface of cancer cells and target them for destruction. Like NK cells, CT cells attach to the cancer cell and inject powerful enzymes into it, eventually leading the cancer cell to cause its own cell death. Cortisol, adrenaline, and norepinephrine reduce the ability of CT cells to see cancer cells and tumors.

Adrenaline and norepinephrine both act in the cancer and tumor microenvironment by allowing tiny one-millimeter tumors to create their own blood supply. This process of creating new blood vessels is called angiogenesis.

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How Bowel Cancer Develops

The colon and rectum together are known as the large bowel. Bowel cancer usually affects the large bowel. Cancer of the large bowel is also known as colorectal cancer and might be called colon cancer or rectal cancer, depending on where it starts in the bowel.

is a rare type of cancer.

Illustration above adapted from original illustration, courtesy of the Cancer Council Victoria.

The bowel is part of the digestive system. The digestive system starts at the mouth and ends at the anus. It helps the body break down food and turn it into energy. It also gets rid of the parts of food the body does not use.

The bowel is the long tube that absorbs water and nutrients from food and processes waste products into faeces .

The development of bowel cancer generally takes many years. It usually begins in the lining of the colon or rectum.

If untreated, bowel cancer can grow deeper into the wall of the bowel. From there, it can spread to lymph nodes in the area. Later, bowel cancer can spread to the liver or lungs.

Are There Other Causes Of Fatigue With Colorectal Cancer

Colon Cancer Symptoms, Causes, and Prevention

Yes. Other fatigue-causing factors of colorectal cancer and its treatment include:

  • Tumor cells competing for nutrients
  • Nutritional deficiencies that result from the side effects of treatments, such as nausea, vomiting, mouth sores, taste changes, heartburn, or diarrhea
  • Anemia reduced blood counts from chemotherapy may lead to anemia, a blood disorder in which tissues don’t get enough oxygen.
  • Medicines used to treat side effects such as nausea, pain, depression, anxiety, and seizures
  • Chronic, severe pain
  • Stress from dealing with the disease and the “unknowns,” as well as from worrying about daily accomplishments or trying to meet the expectations of others
  • Trying to maintain your normal daily routine and activities during treatments modifying your schedule and activities can help conserve energy.
  • Depression

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Beyond The Cancer Microenvironment Effects Of Stress On Cancer Spread

The majority of mutated cells die on their journey through the body, or are picked off by the immune system. A research study published in Cancer Research demonstrated that epinephrine not only suppressed the immune system when cancer cells were on the move, it removed any road blocks regarding movement and migration of cancer cells, allowing the process of metastasis to happen.

However, under prolonged stress, the hormones adrenaline and norepinephrine can increase the migration of cancer cells. In Cancer Research, evidence was presented that found norepinephrine to increase the movement and migration of colon-cancer cells. It was also found that adrenaline and norepinephrine allow cancer cells to release enzymes that dissolve the protective layer around organs, allowing the cancer cells to invade those organs.

Symptoms Of Bowel Cancer

Bowel cancer can develop with no symptoms. So, it is important to participate in screening.

Symptoms may include:

Having these symptoms does not mean that you have bowel cancer. People experiencing these symptoms should speak to their doctor.

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Bowel Cancer Risk Factors

The causes of bowel cancer are not clearly understood. Regular screening is important because bowel cancer can develop without noticeable symptoms.

The risk of bowel cancer is greater if you:

  • Are aged 50 and over .
  • Have had an inflammatory bowel disease , particularly if you have had it for more than 8 years.
  • Have previously had special types of polyps in the bowel or a large number of polyps in the bowel.
  • Flexible sigmoidoscopy.

Losing My Mind With Fear Of Colon Cancer

Abdominal distension colon cancer REVIEW

Scared. You honestly sound exactly like me! Im panicking I have bowel cancer at 23 too. I have done a FOB test which has come back as negative and my blood tests show no sign of anemia and my liver and kidney functions are perfect. Ive been researching loads and Im honest to God convince I have cancer as I have every symptom of it. I had really bad abdominal pain about a month ago but that thankfully hasnt come back. I hope we are both OK.

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Constipation Does Not Cause Colon Cancer:

It has been a debate of decades to establish the meaningful relationship between constipation being causative and colon cancer as the result. For long, constipation has been considered a cause of colon cancer. This could be true partly because in constipation, the bowel movement slows down. In turn, it causes greater time of interaction between the colon lining and the cancerous particles contained in stool. This hypothesis constructed in the end of 20th century is now refuted. Recent researches indicate no direct link of constipation causing colon cancer . They further clear that any past evidences favoring the notion could be the result of poor research quality.

Adding to list, having chronic constipation can, in fact, lower the risk of having colon cancer . This positive association is observed through colonoscopy in the patients, with the chief complaint of constipation, screened for colon cancer risk.

What Causes Fatigue With Colorectal Cancer

The exact reason for colorectal cancer-related fatigue is unknown. It may be related to the disease itself or its treatments.

The following colorectal cancer treatments are commonly associated with fatigue:

  • Chemotherapy. Any chemotherapy drug or regimen may cause fatigue. Fatigue usually develops after several weeks of chemotherapy. In some, fatigue lasts a few days, while others say the problem persists throughout the course of treatment and even after the treatment is complete.
  • Radiation therapy.Radiation, commonly used in the treatment of rectal cancer, can cause fatigue that increases over time. This can occur regardless of the treatment site. Fatigue usually lasts from 3 to 4 weeks after treatment stops, but can continue for up to 2 to 3 months.
  • Combination therapy. More than one cancer treatment at the same time or one after the other increases the chances of developing fatigue.

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How Stress Affects The Cancer Microenvironment

In addition to the fuel glucose and arachidonic acid, and growth factors including insulin and 16hydroxyestrone, the stress hormones adrenaline, norepinephrine, and cortisol play a major role in all steps of the development and progression of cancer. A study published in Nature Reviews found that the release of stress hormones can compromise DNA repair mechanisms, leading to the development of cancer. As cancer develops into a tumor, the hormones cortisol, adrenaline, and epinephrine have a major impact on the biology of the tumor and its surrounding environment.

Often cancer evades the immune system through different mechanisms. Natural Killer cells are cytotoxic lymphocytes that rapidly respond to infectious agents and tumor formation. Their role is to seek and destroy cancer cells, as well as cells infected by viruses.

Whats The Outlook For People With Colon Cancer

Stressful Job can cause Cancer

It can be alarming and stressful to get a serious diagnosis like colon cancer. Fortunately, colon cancer is treatable, especially when detected early. In fact, according to the ACS, colon cancer thats diagnosed before it has spread past the colon and rectum has a . Additionally, these survival rates are based on data from 2010 to 2016. New cancer treatments have led to increasingly improved outcomes in more recent years.

However, colon cancer cases have also risen among younger people in recent years. According to the , while colon cancer deaths declined in older adults, deaths in people younger than 50 years old increased between 2008 and 2017.

Colon cancer stageat diagnosis Survival rate

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Stress Inflammation And Neurodegenerative Diseases

The role of stress and inflammation are being recognized in neurodegenerative disease. AD and PD are the two most common neurodegenerative diseases. Extracellular amyloid protein accumulation is currently seen as a key step in the pathogenesis of AD. PD is characterized by progressive loss of nigrostriatal dopaminergic neurons and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. The potential etiology and molecular mechanisms underlying the pathogenesis of AD and PD remains unknown and have not been completely elucidated. However, some progress has been made in identifying the risk factors. During the last two to three decades, increasing evidence from animal and clinical studies has implicated stress and neuroinflammation as risk factors and may play a fundamental part in the pathogenesis of AD and PD.

The Stress And Cancer: What Can You Do About It

At the end of the day, all you can do is to try and create as inhospitable a terrain for cancer as possible, so that regardless of the triggers, the cancer cells dont grow, says Cohen.

It makes sense, for instance, to handle high-stress times with healthful habits that not only reduce your agita, but also lower your risk of a host of diseases besides cancer, including diabetes, heart disease, and Alzheimers.

Healthful habits, Ocean says, means exercising instead of pigging out, or doing yoga rather than throwing down a few shots over the weekend.

Also crucial: A good support network, and prioritizing whats important and meaningful in your life, says Cohen. If you can figure out what you care about, you can use those core values to guide your decision-making, which makes for a less stressful, higher quality of life in anyone, with or without cancer.

Experts also recommend engaging in some kind of mind-body practice, including deep, diaphragmatic breathing for a few minutes a day.

Studies have shown this kind of breathing actually stimulates the parasympathetic nervous system, which tends to calm the body, says Cohen.

A meta-analysis published in the British Journal of Cancer looked at the link between exercise and colon cancer risk and found that the most physically active people had a 24 percent lower risk of colon cancer than those who were the least active. Studies focusing on the occurrence of breast cancer have shown similar benefits of exercise.

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Effect Of Chronic Psychological Stress On Liver Metastasis Of Colon Cancer In Mice

  • Affiliation Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • * E-mail:

    Affiliations Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • * E-mail:

    Affiliation Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • Affiliation Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • Affiliation Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • Affiliation Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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