Causes Of High Protein
There may be various factors responsible for high protein amount in urine. Dehydration, high blood pressure, diabetes mellitus, glomerulonephritis, autoimmune problems, and chronic kidney disease, etc. Apart from that, many other factors such as intake of certain medicines, dehydration, and intense physical activities may be responsible for protein loss in urine. proteinuria treatment emphasises on managing its causative factors.
The Rise In Popularity Of High
The estimated average requirement for protein intake is 0.6 g of protein per kilogram of ideal body weight per day, which corresponds to the amount of protein required to avoid negative nitrogen balance and to meet half of a populations requirements. The recommended daily allowance for protein intake is 0.83 g/kg per day and is calculated to meet the requirements of 97%98% of the population . Although there is a lack of consensus regarding the formal definition of a high-protein diet, most definitions set a threshold between 1.2 and 2.0 g/kg per day. Within this range, protein consumption > 1.5 g/kg per day is generally considered to be a high-protein diet. Data from the National Health and Nutrition Examination Survey show that the current average consumption of protein in the United States is estimated to be approximately 1.21.4 g/kg per day, which is higher than the recommended amount. Popular weight-loss diets encourage higher amounts of protein while restricting the amount of carbohydrates, based on the assumption that all carbohydrates are undesirablean assumption that has been refuted in the literature. Although such diets vary, these weight-loss strategies typically recommend that 25%35% of calories consumed should be from protein and < 45% of calories should be from carbohydrates . In extreme cases, such as the ketogenic diet, < 5%10% of calories are from carbohydrates.
Is There Anything Else I Need To Know About A Protein In Urine Test
At-home test kits that check for protein in urine test are available without a prescription. The kits usually include dipsticks and instructions for how to collect and test your urine sample. At-home urine tests are easy to do and provide accurate results as long as you carefully follow all instructions. Ask your provider which protein in urine test is best for you.
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What If Proteinuria Is Present Without Inflammation Or Bleeding
If proteinuria is present and there is no sign of inflammation or bleeding, then serious kidney disease may exist. The best test to determine the severity of the problem is the urine protein:creatinine ratio . A protein:creatinine ratio that remains persistently high is a reliable indicator of serious kidney disease and possibly kidney failure. Further investigation is recommended and could include doing blood tests to assess kidney function, testing for bacterial infection or infectious disease, performing an ultrasound of the kidneys and possibly doing a kidney biopsy. Once a diagnosis has been made, effective management of the problem may be possible.
|Contributors: Malcolm Weir, DVM, MSc, MPH Kristiina Ruotsalo, DVM, DVSc, Dip ACVP Margo S. Tant BSc, DVM, DVSc|
Detecting And Quantifying Proteinuria
Dipstick analysis is used in most outpatient settings to semiquantitatively measure the urine protein concentration. In the absence of protein, the dipstick panel is yellow. Proteins in solution interfere with the dye-buffer combination, causing the panel to turn green. False-positive results occur with alkaline urine when the dipstick is immersed too long with highly concentrated urine with gross hematuria in the presence of penicillin, sulfonamides or tolbutamide and with pus, semen or vaginal secretions. False-negative results occur with dilute urine and when the urinary proteins are nonalbumin or low molecular weight.
The results are graded as negative , trace , 1+ , 2+ , 3+ or 4+ . This method preferentially detects albumin and is less sensitive to globulins or parts of globulins .12
The sulfosalicylic acid turbidity test qualitatively screens for proteinuria. The advantage of this easily performed test is its greater sensitivity for proteins such as Bence Jones. The SSA method requires a few milliliters of freshly voided, centrifuged urine. An equal amount of 3 percent SSA is added to that specimen. Turbidity will result from protein concentrations as low as 4 mg per dL . False-positive results can occur when a patient is taking penicillin or sulfonamides and within three days after the administration of radiographic dyes. A false-negative result occurs with highly buffered alkaline urine or a dilute specimen.
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How Is Pediatric Proteinuria Diagnosed
If you or your childs pediatrician suspect that your child has proteinuria, a condition in which protein leaks from the blood into the urine, the doctor will recommend a urine test.
In the past, a 24-hour urine collection was required to diagnose proteinuria. The patient would collect urine in a single container from the first visit to the bathroom in the morning through the first visit on the next day. This test may still be used, but most of the time, a simple urine test can be done in a doctors office to test how much protein is in your childs urine. A chemically-treated paper dipped into the urine sample will change color if protein levels are high.
If your child has no symptoms and a urine sample collected first thing in the morning indicates no protein or only trace amounts, the doctor may suggest that your child be tested again in a year. If protein is discovered in the urine, another first morning sample should be tested and also examined under a microscope, and further urinalysis the physical, chemical, and microscopic testing of a sample of urinewill be necessary. If the urine tests reveal excess protein and urinalysis results are abnormal, your child may need further evaluation because if the proteinuria persists, it can mean that your childs kidney function is declining.
The Role Of Stress On Urinary Tract Symptoms
Stress affects the bladderand can affect urine retention and storage. Lower urinary tract symptoms is a word that describes a series of symptoms triggered by infections, obstruction, or irritation of the bladder.6
While these symptoms can affect both male and female genders, experts record a higher percentage of cases in men. Since these symptoms interfere with the proper functioning of organs, patients may find it challenging to live their daily lives.
In addition, stress is a condition known to worsen urinary tract functions because it triggers frequent urination, signaling lower retention ability.
Experts also believe that stress plays a significant role in bladder dysfunction, particularly in children. This may cause bedwetting or the inability to retain urine for an extended period.
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When To Talk With A Healthcare Professional
When you see blood in your urine or notice a pinkish color, you may need to talk to a health specialistthere are different degrees of hematuria.
Gross hematuria is a degree of hematuria that is visible to the eyes. You can see your urine turn red or pink with this category.
On the other hand, microscopic hematuria means you need a microscope to see the blood. This usually means the amount of blood present is tiny for the naked eyes.
Hematuria is not the only reason your blood changes color. In some instances, food or fruits you eat may result from changes in urine color, making it necessary to conduct a urinalysis.
There may be a need to talk to a healthcare professional when:
You can diagnose hematuria in different ways. Here are some common ways to detect blood in urine:
- Urinalysis: Urinalysis is a urine test that checks for glucose, crystals, protein, and blood. Doctors recommend this test for patients who show signs of UTI or diabetes.
- Urine culture: This is a test conducted by health professionals to check germs or bacteria in the urine, resulting in an infection. This test may also help you diagnose
- Cystoscopy: This is another test for hematuria. The professional checks the bladder to find the possible cause of bleeding.
What Causes Protein In The Urine
Healthy kidneys remove extra fluid and waste from your blood and transform it into urine. Healthy kidneys do not remove proteins and other important nutrients, which pass through and return to your blood. But when your kidneys are damaged, they may let this protein leak into your urine. This causes high levels of protein in your urine.
Anyone can have protein in their urine. You may be more likely to have protein in your urine if you have one or more of the risk factors for kidney disease. There are health problems that can cause long-lasting protein in the urine, and some that can cause short-term protein in the urine.
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Can Stress Cause Blood In Urine
Studies show that stress may worsen lower urinary tract disorders.1 Similarly, psychological or emotional stress may aggravate bladder conditions, such as increased urination. However, research has not proven the correlation between stress and hematuria
Stress is a condition everyone faces at some point in time. Some experts describe stress as a physical or emotional tension, which is characterized by anger or frustration.2 Also, people become stressed when overwhelmed with new conditions or situations.
When you encounter an overwhelming situation, your body reacts to itmaking you tired or frustrated. While stress is vital for helping you fulfill your daily goals, it may lead to other health concerns when it becomes consistent.
While studies have not successfully linked stress as a direct cause of blood in urine, most assert that chronic stress can aggravate lower functional urinary tract disorders.
In a study conducted on rats, the investigators exposed some rats to stressful conditions.3 When comparing the stressed rats and controls, there were weak differences between the two.
For one, the stressed rats frequently urinated, which can be perceived as an effect of chronic stress. Similarly, those rodents also had increased mass cells in bladder tissues. Finally, they exhibited anxiety-like behavior.
Below are common reasons for hematuria:
What Do The Results Mean
If a large amount of protein is found in your urine sample, it doesn’t always mean that you have a medical problem that needs treatment. Strenuous exercise, dehydration, diet, stress, pregnancy, and other conditions can cause a temporary rise in urine protein levels.
Your provider may recommend other urinalysis tests to see whether you continue to have a high level of protein in your urine over time. If your urine protein remains high, it is likely a sign of kidney disease or kidney damage from other conditions.
The amount of protein in your urine is linked to the amount of kidney damage you may have. But you will need more tests to diagnose what is causing the damage. To learn what your results mean, talk with your provider.
Learn more about laboratory tests, reference ranges, and understanding results.
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Stress And Your Kidneys
We all experience stress. Its part of life. But too much stress can contribute to poor health, increasing our blood pressure and damaging our kidneys. By learning how stress impacts our health and finding ways to manage it, we can keep our kidneys healthier and live a healthier life overall.
What is stress?Stress is anything that can upset or disturb your equilibrium or balance. Stress can be physiological , or psychological . Living with a chronic illness, such as kidney disease, or learning for the first time that you have a chronic illness can be a significant source of stress.
Psychological stress is something that we contend with every day. It can be a result of positive life events, such as marriage and children, or it can come from more emotionally challenging events, such as the loss of a loved one, divorce and personal or financial problems.
Stress is normal, and your physical response to stress, including faster breathing and heart rate, a spike in blood pressure, dilated pupils, tense muscles, is a natural and normal process. The levels of fats and sugars in your blood can also increase. The bodys response to stress is commonly known as fight or flight. Although it is a natural process to help us survive immediate dangers, these reactions from too much or constant stress can eventually take their toll on your health.
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Pycnogenol Added To Ace Inhibitors A Type Of Blood Pressure Medication
A natural treatment added to the ACE inhibitor ramipril improved blood pressure, kidney function, protein in urine, and blood glucose over ramipril alone. What are ACE inhibitors? ACE inhibitors are a group of medicines that are used in the treatment of high blood pressure and heart failure. ACE inhibitor stands for angiotensin-converting enzyme inhibitor which include captopril, enalapril, fosinopril, imidapril, lisinopril, moexipril, perindopril, quinapril, and ramipril. Ace inhibitors work by reducing angiotensin converting enzyme which lowers blood pressure by dilating and relaxing blood vessels.
Cesarone MR et al also reported that adding Pycnogenol found that albumin levels in the urine decreased significantly in the Pycnogenol group compared to ramipril alone . Pycnogenol was noted to improve systolic and diastolic flow by 12% and 8%, respectively.
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What Is The Most Likely Cause Of Protein In Urine
There is a question about what causes theuria. Non-cancerous or temporary medical conditions are some of the reasons why proteinuria can be caused. Dehydration, inflammation and low blood pressure are some of the symptoms. Aspirin therapy, emotional stress, and exposure to cold are some of the things that can causeProteinuria.
What Happens During A Protein In Urine Test
You will need to give a urine sample for the test. A health care professional may give you a cleansing wipe, a small container, and instructions for how to use the “clean catch” method to collect your urine sample. It’s important to follow these instructions so that germs from your skin don’t get into the sample:
If you have hemorrhoids that bleed or are having your menstrual period, tell your provider before your test.
In certain cases, your provider may ask you to collect all of your urine during a 24-hour period. A “24-hour urine sample test” may provide more complete results, because the amount of protein and other substances in urine can vary throughout the day.
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How Is Protein In Urine Diagnosed
Testing for protein in urine is typically done via a test called a urinalysis. This simple urine test can detect protein levels in the urine and can be conducted in a doctors office. After your urine sample is collected, it is tested with a dipstick. When your urine has large amounts of protein, the strip of paper will change color. Technicians may also examine the sample via microscope.
If a urinalysis detects protein in the urine, your doctor will likely order an additional urine test or tests to determine if you have kidney disease. Your doctor may also conduct blood tests to measure your glomerular filtration rate , which can tell them how well your kidneys are filtering out waste, as well as other blood tests if needed to help identify the cause of the proteinuria. Additional tests may include an ultrasound, CT scan, or kidney biopsy.
When your urine is tested for protein, the test compares the amounts of albumin and creatinine, an amino acid, in your urine. A urine albumin-to-creatinine ratio higher than 30 milligrams per gram observed more than twice over a three-month period may indicate kidney disease.
If you get an abnormal result that detects protein in urine, your doctor will also probably want to check your cholesterol levels, blood sugar, and blood pressure to determine what conditions might be contributing to proteinuria.
Causes Of Protein In The Urine
Your kidneys, when working properly, filter waste products from your blood. They return protein and other materials that your body needs to function.
Some conditions and diseases can cause the level ofprotein in your urine to rise. Short term conditions that cause protein in the urine can include strenuous exercise, fever, heat or cold exposure and emotional distress. Long term conditions and diseases that can lead to protein in the urine include high blood pressure, kidney infection or disease, heart disease, diabetes, lupus and malaria.If a urine test reveals protein in your urine, your doctor may recommendfurther testing to determine the cause. Test may include a 24-hour urine collection to determine whether the protein in your urine is cause for concern. Your doctor may also follow up with an ultrasound or CT scan to look for issues like kidney stones or a biopsy to see what has caused damage to your kidneys.
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S To Take At Stage 1 Kidney Disease
- See your doctor regularlyget medical attention for any unusual or unexplained health symptoms.
- Know your GFRask your doctor for a blood test to calculate your estimated glomerular filtration rate , so you can monitor your kidney health.
- Treat underlying health conditionstalk to your doctor about high blood pressure, diabetes, or other health conditions that can contribute to kidney disease.
- Make healthy lifestyle choicesquit smoking, exercise regularly, eat well , reduce stress, and get enough sleep.
- Take all medications as prescribedand talk to your doctor before taking any over-the-counter medications.